One of the most anticipated games out there that I have seen has to be spore. If you haven't herd of it you may want to simply crawl out from under that rock you've been under, rip you lips from the person you've been smooching, or simply take a look into the gaming media domain.
Spore is a game that blows away anything that has ever really been attempted in a simulation game before. All you really do is lead organisms from microscopic all the way to galaxy domination, experiencing every evolutionary step of the way.
Been waiting and still can't wait for this.